MAIA Biotechnology, Inc. is a clinical-stage biopharmaceutical company developing targeted immunotherapies for cancer. The Company's THIO (6-thio-dG, 6-thio-2'-deoxyguanosine) is a first-in-class investigational telomere-targeting agent in clinical development to evaluate its activity in Non-Small Cell Lung Cancer (NSCLC).
The modified nucleotide 6-thio-2-deoxyguanosine (THIO) induces telomerase-dependent telomeric DNA modification, DNA damage responses, and selective cancer cell death. THIO-damaged telomeric fragments accumulate in cytosolic micronuclei and activates both innate (cGAS/STING) and adaptive (T-cell) immune responses.
The sequential treatment with THIO followed by PD-(L)1 inhibitors resulted in tumor regression in advanced, in vivo cancer models by induction of cancer type-specific immune memory. THIO is being developed as a second or later line of treatment for NSCLC for patients that have progressed beyond the standard-of-care regimen of existing checkpoint inhibitors..
| Price and Volume | |
|---|---|
| Volume | |
| Ten Day Average Volume | 63.6K | 
| Three Month Average Volume | 5.1M | 
| High Low | |
| Fifty-Two Week High | 5.99 USD | 
| Fifty-Two Week Low | 0.82 USD | 
| Fifty-Two Week High Date | 03 Jun 2024 | 
| Fifty-Two Week Low Date | 11 Dec 2023 | 
| Price and Volume | |
| Current Price | 3.04 USD | 
| Beta | -100,000 | 
| Relative Price Change | |
| Four Week Relative Price Change | -2.46% | 
| Thirteen Week Relative Price Change | -40.20% | 
| Twenty-Six Week Relative Price Change | 98.19% | 
| Fifty-Two Week Relative Price Change | 38.63% | 
| Year-to-Date Relative Price Change | 119.41% | 
| Price Change | |
| One Day Price Change | 8.57% | 
| Thirteen Week Price Change | -36.00% | 
| Twenty-Six Week Price Change | 117.92% | 
| Five Day Price Change | 2.01% | 
| Fifty-Two Week Price Change | 73.71% | 
| Year-to-Date Price Change | 159.83% | 
| Month-to-Date Price Change | -5.88% | 
| Per Share Data | |
|---|---|
| Book Value | |
| Book Value Per Share (Last Fiscal Year) | 0.02811 USD | 
| Book Value Per Share (Most Recent Quarter) | 0.1332 USD | 
| Tangible Book Value Per Share (Last Fiscal Year) | 0.02811 USD | 
| Tangible Book Value Per Share (Most Recent Quarter) | 0.1332 USD | 
| EBITD | |
| EBITD Per Share (Trailing Twelve Months) | -1.1077 USD | 
| Revenue | |
| Revenue Per Share (Last Fiscal Year) | 0 USD | 
| Revenue Per Share (Trailing Twelve Months) | 0 USD | 
| Dividend | |
| Dividend Per Share (Last Fiscal Year) | -99999.99 USD | 
| Dividend Per Share (Trailing Twelve Months) | 0 USD | 
| Dividend Per Share (5 Year) | -99999.99 USD | 
| Earnings Per Share | |
| Excluding Extraordinary Items (Last Fiscal Year) | -1.49099 USD | 
| Excluding Extraordinary Items (Trailing Twelve Months) | -1.61888 USD | 
| Normalized (Last Fiscal Year) | -1.49099 USD | 
| Basic Excluding Extraordinary Items (Last Fiscal Year) | -1.49099 USD | 
| Basic Excluding Extraordinary Items (Trailing Twelve Months) | -1.61888 USD | 
| Including Extraordinary Items (Last Fiscal Year) | -1.49099 USD | 
| Including Extraordinary Items (Trailing Twelve Months) | -1.61888 USD | 
| Cash | |
| Cash Per Share (Last Fiscal Year) | 0.42097 USD | 
| Cash Per Share (Most Recent Quarter) | 0.4878 USD | 
| Cash Flow Per Share (Last Fiscal Year) | -99999.99 USD | 
| Cash Flow Per Share (Trailing Twelve Months) | -99999.99 USD | 
| Free Cash Flow Per Share (Trailing Twelve Months) | -0.89447 USD | 
| Margins | |
|---|---|
| Cash Flow Revenue | |
| Cash Flow Revenue (5 Year) | -100,000 | 
| Cash Flow Revenue (Trailing Twelve Months) | -100,000 | 
| Pretax Margin | |
| Pretax Margin (Trailing Twelve Months) | -99,999.99% | 
| Pretax Margin (Last Fiscal Year) | -99,999.99% | 
| Pretax Margin (5 Year) | -99,999.99% | 
| Gross Margin | |
| Gross Margin (Last Fiscal Year) | -99,999.99% | 
| Gross Margin (Trailing Twelve Months) | -99,999.99% | 
| Gross Margin (5 Year) | -99,999.99% | 
| Operating Margin | |
| Operating Margin (Last Fiscal Year) | -99,999.99% | 
| Operating Margin (Trailing Twelve Months) | -99,999.99% | 
| Operating Margin (5 Year) | -99,999.99% | 
| Net Profit Margin | |
| Net Profit Margin (Last Fiscal Year) | -99,999.99% | 
| Net Profit Margin (Trailing Twelve Months) | -99,999.99% | 
| Net Profit Margin (5 Year) | -99,999.99% | 
| Growth | |
|---|---|
| Book Value | |
| Book Value Per Share (5 Year) | -99,999.99% | 
| Tangible Book Value (5 Year) | -99,999.99% | 
| Free Operating Cash Flow | |
| Free Operating Cash Flow (5 Year) | -99,999.99% | 
| Revenue | |
| Revenue Change MRQ vs 1 Year Ago | -99,999.99% | 
| Revenue Growth (3 Year) | -99,999.99% | 
| Revenue Change (Trailing Twelve Months) | -99,999.99% | 
| Revenue Per Share Growth | -99,999.99% | 
| Revenue Growth (5 Year) | -99,999.99% | 
| Capital Spending Debt | |
| Capital Spending (5 Year) | -99,999.99% | 
| Total Debt (5 Year) | -99,999.99% | 
| Dividends | |
| Dividend Growth (3 Year) | -99,999.99% | 
| Earnings Per Share | |
| EPS Change MRQ vs 1 Year Ago | -13.91% | 
| EPS Change (Trailing Twelve Months) | -2.04% | 
| EPS Growth (3 Year) | -99,999.99% | 
| EPS Growth (5 Year) | -99,999.99% | 
| EBITDA | |
| EBITDA (5 Year) | -99,999.99% | 
| EBITDA (5 Year Interim) | -99,999.99% | 
| Net Profit Margin | |
| Net Profit Margin Growth (5 Year) | -99,999.99% | 
| Valuation | |
|---|---|
| Total Price to Book | |
| Price to Tangible Book (Last Fiscal Year) | 152 | 
| Price to Tangible Book (Most Recent Quarter) | 23 | 
| Price to Free Cash Flow | |
| Price to Free Cash Per Share (Last Fiscal Year) | -100,000 | 
| Price to Free Cash Per Share (Trailing Twelve Months) | -100,000 | 
| Net Debt | |
| Net Debt (Most Recent Quarter) | -11,579,390 | 
| Net Debt (Last Fiscal Year) | -7,150,700 | 
| Price to Sales | |
| Price to Sales (Last Fiscal Year) | -100,000 | 
| Price to Sales (Trailing Twelve Months) | -100,000 | 
| Price to Earnings | |
| PE Excluding Extraordinary Items (Last Fiscal Year) | -100,000 | 
| PE Normalized (Last Fiscal Year) | -100,000 | 
| PE Basic Excluding Extraordinary Items (Trailing Twelve Months) | -100,000 | 
| PE Excluding Extraordinary Items High (Trailing Twelve Months) | -100,000 | 
| PE Excluding Extraordinary Items Low (Trailing Twelve Months) | -100,000 | 
| PE Including Extraordinary Items (Trailing Twelve Months) | -100,000 | 
| Dividends | |
| Dividend Yield (5 Year) | -99,999.99% | 
| Dividend Yield | -99,999.99% | 
| Current Dividend Yield | 0.00% | 
| Price to Book | |
| Price to Book (Last Fiscal Year) | 108 | 
| Price to Book (Most Recent Quarter) | 23 | 
| Financial Strength | |
|---|---|
| Debt to Equity | |
| Long Term Debt to Equity (Last Fiscal Year) | 0 | 
| Long Term Debt to Equity (Most Recent Quarter) | 0 | 
| Payout Ratio | |
| Payout Ratio (Last Fiscal Year) | -99,999.99% | 
| Payout Ratio (Trailing Twelve Months) | -99,999.99% | 
| Quick Ratio | |
| Quick Ratio (Last Fiscal Year) | -100,000 | 
| Quick Ratio (Most Recent Quarter) | -100,000 | 
| Enterprise Value | |
| Current Enterprise Value to Free Cash Flow (Last Fiscal Year) | -100,000 | 
| Current Enterprise Value to Free Cash Flow (Trailing Twelve Months) | -100,000 | 
| Current Ratio | |
| Current Ratio (Last Fiscal Year) | 2 | 
| Current Ratio (Most Recent Quarter) | 3 | 
| Free Cash Flow | |
| Free Cash Flow (Last Fiscal Year) | -13,071,020 | 
| Free Cash Flow (Trailing Twelve Months) | -15,421,310 | 
| Net Interest Coverage | |
| Net Interest Coverage (Last Fiscal Year) | -100,000 | 
| Net Interest Coverage (Trailing Twelve Months) | -100,000 | 
| Total Debt to Equity | |
| Total Debt to Equity (Last Fiscal Year) | 0 | 
| Total Debt to Equity (Most Recent Quarter) | 0 | 
| Management Effectiveness | |
|---|---|
| Return on Assets | |
| Return on Assets (Last Fiscal Year) | -201.88% | 
| Return on Assets (Trailing Twelve Months) | -251.96% | 
| Return on Assets (5 Year) | -99,999.99% | 
| Return on Equity | |
| Return on Equity (Last Fiscal Year) | -440.12% | 
| Return on Equity (Trailing Twelve Months) | -559.56% | 
| Return on Equity (5 Year) | -99,999.99% | 
| Return on Investment | |
| Return on Investment (Last Fiscal Year) | -347.42% | 
| Return on Investment (Trailing Twelve Months) | -362.21% | 
| Return on Investment (5 Year) | -99,999.99% |